What is the most important information I should know about
                                POTELIGEO?
                            
                            
                                POTELIGEO may cause serious side effects that can be severe or life-threatening
                                including
                                skin problems, infusion reactions, infections, autoimmune problems, and complications
                                from stem cell transplant.
                            
                            
                                
                                    Call or see your healthcare provider right away if you develop any symptoms of the
                                    following
                                    problems or if these symptoms get worse:
                                
                                
                                    
                                        - 
                                            Skin problems: Signs and symptoms of skin
                                            reactions may include skin
                                            pain,
                                            itching, skin blistering or peeling, rash, painful sores or ulcers in your
                                            mouth, nose,
                                            throat
                                            or genital area.
                                        
- 
                                            Infusion reactions: Signs and symptoms of
                                            infusion reactions may
                                            include chills or
                                            shaking, redness on your face (flushing), itching or rash, shortness of
                                            breath, coughing
                                            or wheezing,
                                            dizziness, feeling like passing out, tiredness, fever.
                                        
- 
                                            Infections: Signs and symptoms of
                                            infection may include fever, sweats
                                            or chills,
                                            nausea, flu-like symptoms, sore throat or difficulty swallowing, shortness
                                            of breath,
                                            diarrhea or
                                            stomach pain, cough.
                                        
- 
                                            Autoimmune problems: Some people receiving
                                            POTELIGEO may develop
                                            autoimmune problems,
                                            and some people who already have an autoimmune disease may get worse during
                                            treatment
                                            with POTELIGEO.
                                        
- 
                                            Complications of stem cell transplant:
                                            Patients who receive a stem cell
                                            transplant
                                            using donor stem cells (allogeneic) after treatment with POTELIGEO may
                                            experience
                                            complications that
                                            can be severe and lead to death. Your healthcare provider will monitor you
                                            for signs of
                                            complications
                                            if you have an allogeneic stem cell transplant.
                                        
 
                                What are the most common side effects of POTELIGEO?
                                
                                
                                    The most common side effects of POTELIGEO include rash, tiredness, diarrhea, muscle
                                    and bone pain, and upper respiratory tract infection.
                                
                                
                                    Before starting POTELIGEO treatment, tell your doctor about all your medical
                                    conditions,
                                    including whether you:
                                
                                
                                    
                                        - 
                                            have had a severe skin reaction after receiving POTELIGEO
                                        
- 
                                            have had an infusion reaction during or after receiving POTELIGEO
                                        
- 
                                            have or have had liver problems including hepatitis B (HBV) infection
                                        
- 
                                            have a history of autoimmune problems
                                        
- 
                                            have undergone or plan to have a stem cell transplant, using cells from a
                                            donor
                                        
- 
                                            have lung or breathing problems
                                        
- 
                                            are pregnant or plan to become pregnant
                                            - It is not known
                                                if POTELIGEO will harm your unborn baby 
- 
                                            are breastfeeding or plan to breastfeed
                                            - Talk to your
                                                healthcare provider about the best way to feed your baby during
                                                treatment with POTELIGEO 
 
                                
                                    Tell your doctor about all the medicines you take, including prescription and
                                    over-the-counter
                                    medicines, vitamins, and herbal supplements.
                                
                                
                                    You are encouraged to report suspected adverse reactions to Kyowa Kirin, Inc. at
                                    1-844-768-3544 or FDA
                                    at 1-800-FDA-1088  or www.fda.gov/medwatch.
                                
                                Please see full  Prescribing Information as well as Patient Information.