Cutaneous T-cell lymphoma (CTCL) is a rare form of cancer that starts in a type of white blood cell called a T cell

  • Healthy T cells are part of the immune system. They help the body fight infection
  • CTCL develops when your T cells grow uncontrollably and become cancerous

There are several types of CTCL; Mycosis Fungoides (MF) and Sézary Syndrome (SS) are the most common

  • In MF and SS, cancerous T cells are usually found in the skin first
    - T cells in the skin may appear as a flat area called a patch, or a slightly raised area called a plaque
    - This can cause sunburn-like redness or rash, and sometimes skin tumors
  • In addition to the skin, cancerous T cells can spread and grow in the blood, lymph nodes, or other organs in the body
    - Lymph nodes are found in many parts of the body, such as the neck, armpit, and groin
mycosis fungoides (MF) cancerous t-cell skin patch
mycosis fungoides (MF) cancerous t-cell skin plaque

Images of MF patchesa

aImages courtesy of Dr Oleg Akilov.

Call or see your healthcare provider right away if you develop any symptoms of the following problems or if these symptoms get worse:

  • Skin problems: Signs and symptoms of skin reactions may include skin pain, itching, skin blistering or peeling, rash, painful sores or ulcers in your mouth, nose, throat or genital area.
  • Infusion reactions: Signs and symptoms of infusion reactions may include chills or shaking, redness on your face (flushing), itching or rash, shortness of breath, coughing or wheezing, dizziness, feeling like passing out, tiredness, fever.
  • Infections: Signs and symptoms of infection may include fever, sweats or chills, nausea, flu-like symptoms, sore throat or difficulty swallowing, shortness of breath, diarrhea or stomach pain, cough.
  • Autoimmune problems: Some people receiving POTELIGEO may develop autoimmune problems, and some people who already have an autoimmune disease may get worse during treatment with POTELIGEO.
  • Complications of stem cell transplant: Patients who receive a stem cell transplant using donor stem cells (allogeneic) after treatment with POTELIGEO may experience complications that can be severe and lead to death. Your healthcare provider will monitor you for signs of complications if you have an allogeneic stem cell transplant.

What are the most common side effects of POTELIGEO?

The most common side effects of POTELIGEO include rash, tiredness, diarrhea, muscle and bone pain, and upper respiratory tract infection.

Before starting POTELIGEO treatment, tell your doctor about all your medical conditions, including whether you:

  • have had a severe skin reaction after receiving POTELIGEO
  • have had an infusion reaction during or after receiving POTELIGEO
  • have or have had liver problems including hepatitis B (HBV) infection
  • have a history of autoimmune problems
  • have undergone or plan to have a stem cell transplant, using cells from a donor
  • have lung or breathing problems
  • are pregnant or plan to become pregnant
    - It is not known if POTELIGEO will harm your unborn baby
  • are breastfeeding or plan to breastfeed
    - Talk to your healthcare provider about the best way to feed your baby during treatment with POTELIGEO

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

You are encouraged to report suspected adverse reactions to Kyowa Kirin, Inc. at 1-844-768-3544 or FDA at 1-800-FDA-1088 or

Please see full Prescribing Information as well as Patient Information.